| Mitochondrial elongation during autophagy: A stereotypical response to survive in difficult times. | |
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MedLine Citation:
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PMID: 21743300 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer mitochondria are protected from being degraded and possess more cristae where activity of the ATP synthase is increased, optimizing ATP production in times of nutrient restriction. |
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Authors:
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Ligia C Gomes; Luca Scorrano |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dulbecco-Telethon Institute at the Venetian Institute of Molecular Medicine; Padova, Italy; PhD Programme in Experimental Biology and Biomedicine; Center for Neuroscience and Cell Biology; University of Coimbra; Coimbra, Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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