Document Detail

Mitochondrial dysfunction--a pathogenetic factor in Parkinson's disease.
MedLine Citation:
PMID:  10991668     Owner:  NLM     Status:  MEDLINE    
The cause of Parkinson's disease is still unknown. Nonetheless, there are some generally accepted hypotheses with respect to the cascade of dopaminergic cell degeneration. One of the factors is a decrease in respiratory chain complex I activity. This enzyme abnormality is only found in substantia nigra pars compacta. It is not currently known whether this is due to a genetic abnormality of the nuclear or mitochondrial genome or to an exo- or endotoxin. To date, no specific abnormality of the mitochondrial genome has been detected, although ageing leads to deletions in up to 5% of all mitochondrial genome molecules in the brain. There is controversy whether this complex I defect is also detectable in muscle or blood cells. It is our conviction that the considerable overlap between blood cells from normal controls and patients with Parkinson's disease means that such measurements are not distinctive for the two conditions. A decrease in complex I activity in postmitotic cells may be one of the crucial factors for cell death.
H Reichmann; B Janetzky
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neurology     Volume:  247 Suppl 2     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  II63-8     Citation Subset:  IM    
Department of Neurology, Technical University of Dresden, Germany.
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MeSH Terms
Mitochondrial Myopathies / genetics*,  pathology*
Parkinson Disease / genetics*,  pathology*

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