Document Detail


Mitochondrial dysfunction and heart disease.
MedLine Citation:
PMID:  16120419     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Several inherited and acquired disorders of mitochondria lead to defects in cardiac function as reflected in exercise intolerance, arrhythmias and heart failure. Manifestations of mitochondrial dysfunction is reflected in the abnormal mitochondrial proliferation, structure and ultimately as cytochrome C-induced apoptosis. How these defects are associated with disordered cytosolic events including SR calcium release and transcription has suggested a cross talk of mitochondria and cytosolic events that drive cardiomyocytes dysfunction.
Authors:
Paul Rosenberg
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Publication Detail:
Type:  Journal Article     Date:  2004-10-28
Journal Detail:
Title:  Mitochondrion     Volume:  4     ISSN:  1567-7249     ISO Abbreviation:  Mitochondrion     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2005-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  621-8     Citation Subset:  -    
Affiliation:
Department of Medicine, Duke University, Durham, NC 27710, USA. rosen029@mc.duke.edu
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