| Mitochondrial dysfunction and cell senescence: cause or consequence? | |
| | |
MedLine Citation:
|
PMID: 16608398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of mitochondria in this model. Here, we review evidence supporting the involvement of mitochondria in replicative senescence and a possible link to telomere biology. Moreover, we suggest that this process might be more complex than originally formulated, because variations in nuclear gene expression involved in mitochondrion nucleus cross-talk are observed in both senescence and immortalization. |
| | |
Authors:
|
João F Passos; Thomas von Zglinicki; Gabriele Saretzki |
Related Documents
:
|
9571198 - Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial c... 703398 - Ageing of chick embryo fibroblasts in vitro. ii. relationship between cell proliferatio... 8027538 - Antigen-dependent selection of t cells that are able to efficiently regulate free cytop... 10856888 - Accelerated telomere shortening and senescence in human pancreatic islet cells stimulat... 6815168 - Bromodeoxyuridine-induced molecular species conversion of sialic acids of gangliosides ... 11677098 - T-cell subpopulations in the development of atopic and contact allergy. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Rejuvenation research Volume: 9 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-04-12 Completed Date: 2006-05-31 Revised Date: 2007-09-11 |
Medline Journal Info:
|
Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
|
Languages: eng Pagination: 64-8 Citation Subset: IM |
Affiliation:
|
Henry Wellcome Laboratory for Biogerontology Research, Institute for Aging and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom. Joao.Passos@ncl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Cell Aging / physiology* Cell Division Humans Mitochondria / metabolism, physiology* Oxidative Stress Reactive Oxygen Species / metabolism Telomerase / metabolism Telomere / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Reactive Oxygen Species; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of telomere length and telomerase activity in tree species of various lifespans, and with a...
Next Document: Chromatin modification and senescence: linkage by tumor suppressors?