| Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders. | |
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MedLine Citation:
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PMID: 21289536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autism spectrum disorder (ASD) is a devastating neurodevelopmental disorder. Over the past decade, evidence has emerged that some children with ASD suffer from undiagnosed comorbid medical conditions. One of the medical disorders that has been consistently associated with ASD is mitochondrial dysfunction. Individuals with mitochondrial disorders without concomitant ASD manifest dysfunction in multiple high-energy organ systems, such as the central nervous, muscular, and gastrointestinal (GI) systems. Interestingly, these are the identical organ systems affected in a significant number of children with ASD. This finding increases the possibility that mitochondrial dysfunction may be one of the keys that explains the many diverse symptoms observed in some children with ASD. This article will review the importance of mitochondria in human health and disease, the evidence for mitochondrial dysfunction in ASD, the potential role of mitochondrial dysfunction in the comorbid medical conditions associated with ASD, and how mitochondrial dysfunction can bridge the gap for understanding how these seemingly disparate medical conditions are related. We also review the limitations of this evidence and other possible explanations for these findings. This new understanding of ASD should provide researchers a pathway for understanding the etiopathogenesis of ASD and clinicians the potential to develop medical therapies. |
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Authors:
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Richard E Frye; Daniel A Rossignol |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pediatric research Volume: 69 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-07-22 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 41R-7R Citation Subset: IM |
Affiliation:
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Department of Pediatrics, The Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. richard.e.frye@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child Development Disorders, Pervasive / physiopathology* Humans Mitochondria / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS046565-05/NS/NINDS NIH HHS; K23NS046565/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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