Document Detail


Mitochondrial dynamics in heart failure.
MedLine Citation:
PMID:  22848903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondria have been widely studied for their critical role in cellular metabolism, energy production, and cell death. New developments in research on mitochondria derived from studies in yeast have led to the discovery of entirely new mitochondrial processes that have implications for mitochondrial function in heart failure. Recent studies have identified that maintaining normal mitochondrial morphology and function depends on the dynamic balance of mitochondrial fusion and fission (division). Mitochondrial fusion and fission are constant ongoing processes, which are essential for the maintenance of normal mitochondrial function. Studies in heart failure have been limited but suggest a possible reduction in mitochondrial fusion. As mitochondrial fusion and fission have important links to apoptosis, a key mechanism of loss of cardiac myocytes in heart failure, there are many implications for both heart failure research and treatment.
Authors:
Le Chen; A A Knowlton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  17     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-08-01     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Copyright Information:
2011 Wiley Periodicals, Inc.
Affiliation:
Molecular and Cellular Cardiology Division, Department of Mediicine, University of California, Davis, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Cell Respiration / physiology
Heart Failure / pathology*,  physiopathology*,  therapy
Humans
Mitochondria, Heart / metabolism*,  pathology*
Mitochondrial Proteins / physiology*
Grant Support
ID/Acronym/Agency:
HL077281/HL/NHLBI NIH HHS; HL079071/HL/NHLBI NIH HHS; R01 HL077281/HL/NHLBI NIH HHS; R01 HL079071/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Mitochondrial Proteins
Comments/Corrections

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