Document Detail

Mitochondrial cytochrome concentrations in rat heart and liver as a consequence of different hypoxic periods.
MedLine Citation:
PMID:  179279     Owner:  NLM     Status:  MEDLINE    
Rat heart and liver cytochrome concentrations were determined after three hypoxic conditions (atmospheric pressure 50.5 kPa, 40.8 kPa and 38.0 kPa) lasting one week and two weeks. The heart showed clear hypertrophy which was 38% in most severe hypoxia (38 kPa, 2 weeks). A small decline in the liver weight to body weight ratio was observed, this decrease being 21% in the most severe case. During the hypoxic periods the mitochondrial cytochrome concentration decreased. This phenomenon was more obvious when the degree of hypoxia was increased and more pronounced after 2 weeks than one week. The heart and liver showed quite similar patterns in this respect. In most severe hypoxia the decreases in the liver were 29% for cytochrome aa3, 30% for cytochrome b, 20% for cytochrome c and 15% for cytochrome c1, with the concentrations expressed on mitochondrial protein basis. The corresponding values in the heart were 31%, 43%, 28%, and 22%. It can be concluded that in mammals the mitochondrial cytochrome content probably varies according to the amount of oxygen available.
V L Kinnula
Related Documents :
18488199 - Protection of the right ventricle from ischemia and reperfusion by preceding hypoxia.
6449369 - Effect of freon inhalation on maximal expiratoryflows and heart rhythm after treatment ...
12871679 - Ventilatory chemosensitivity in the chick embryo.
8570309 - Carotid bodies and ventilatory response to hypoxia in aminophylline-treated piglets.
6672919 - Cardiopulmonary response to acute altitude exposure: water loading and denitrogenation.
23699859 - Patients with ards and elevated bmi may need higher than conventional peep to prevent a...
6508019 - Hypoxia-altitude simulation test. evaluation of patients with chronic airway obstruction.
3192409 - Paroxysmal heart block triggered by sitting up: a usually undetected cause of cerebral ...
19321009 - A quality improvement plan for hypertension control: the incoteca project (intervention...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  96     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / metabolism*
Body Weight
Cytochrome c Group / metabolism
Cytochromes / metabolism*
Cytochromes c1 / metabolism
Liver / pathology
Mitochondria, Liver / metabolism*
Mitochondria, Muscle / metabolism*
Myocardium / metabolism*
Organ Size
Time Factors
Reg. No./Substance:
0/Cytochrome c Group; 0/Cytochromes; 9035-42-1/Cytochromes c1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of strength training on enzyme activities and fibre characteristics in human skeletal muscle.
Next Document:  Mechanical and metabolic effects of beta-receptor stimulators, the C-terminal octapeptide of cholecy...