| Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. | |
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MedLine Citation:
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PMID: 21801290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caveolin (CAV) is an essential component of caveolae, cholesterol-enriched invaginations of the plasma membrane of most mammalian cells. However, CAV is not restricted to plasma membrane caveolae, and pools of CAV are present in myriad intracellular membranes. CAV proteins tightly bind cholesterol and contribute to regulation of cholesterol fluxes and distributions within cells. In this context, we recently showed that CAV1 regulates the poorly understood process controlling mitochondrial cholesterol levels. Cholesterol accumulates in mitochondrial membranes in the absence of CAV1, promoting the organelle's dysfunction with important metabolic consequences for cells and animals. In this article, we suggest a working hypothesis that addresses the role of CAV1 within the homeostatic network that regulates the influx/efflux of mitochondrial cholesterol. |
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Authors:
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Marta Bosch; Montserrat Marí; Steven P Gross; José C Fernández-Checa; Albert Pol |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-25 |
Journal Detail:
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Title: Traffic (Copenhagen, Denmark) Volume: 12 ISSN: 1600-0854 ISO Abbreviation: Traffic Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-06 Completed Date: 2012-04-16 Revised Date: 2012-05-04 |
Medline Journal Info:
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Nlm Unique ID: 100939340 Medline TA: Traffic Country: Denmark |
Other Details:
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Languages: eng Pagination: 1483-9 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Equip de Proliferació i Senyalització Cel·lular, Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caveolae / metabolism Caveolin 1 / metabolism* Cholesterol / metabolism* Homeostasis Mice Mitochondria / metabolism* Mitochondrial Membranes / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM64624/GM/NIGMS NIH HHS; R01 GM064624/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caveolin 1; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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