| Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin. | |
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MedLine Citation:
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PMID: 10365247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HeLa cells undergo apoptosis after exposure to cisplatin. Since mitochondria have recently been proposed as a probable effector of this type of cell death, we performed an analysis using the fluorescent cation rhodamine 123, which is transported actively by this organelle. Cisplatin induces a decrease in the mitochondrial staining, as assessed by cytofluorometric analysis. Microscopic analysis demonstrated that this effect was accompanied by damage of the mitochondria. These features were not exclusive of cisplatin, as other antineoplasic agents (taxol, etoposide) elicited similar effects. These results point toward the notion of a general effect of antineoplasic drugs over the mitochondria during induction of apoptotic cell death. |
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Authors:
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J Melendez-Zajgla; E Cruz; V Maldonado; A M Espinoza |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 47 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-08-23 Completed Date: 1999-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 765-71 Citation Subset: IM |
Affiliation:
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Laboratorio de Biología Molecular, Instituto Nacional de Cancerología, México, D. F. emv@hp9000a1.uam.mx |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Antineoplastic Agents, Phytogenic / pharmacology Apoptosis* Cisplatin / pharmacology* Etoposide / pharmacology Flow Cytometry Hela Cells Humans Mitochondria / drug effects* Paclitaxel / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antineoplastic Agents, Phytogenic; 15663-27-1/Cisplatin; 33069-62-4/Paclitaxel; 33419-42-0/Etoposide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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