| Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology. | |
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MedLine Citation:
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PMID: 15614615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the work described in this paper was to evaluate mitochondrial abnormalities in perifascicular atrophic fibers in muscle biopsies from patients with dermatomyositis (DM). We localized cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemically in muscle biopsies of 12 patients with DM, and 12 control patients with neurogenic atrophy. These two histochemical techniques were also combined on single tissue sections in order to accentuate any COX-negative fibers. Eleven out of 12 patients (91.6%) with DM showed histochemical evidence of mitochondrial dysfunction in perifascicular distribution. Similar abnormalities in histochemical staining were not seen in comparably sized myofibers that were atrophic due to denervation. It is concluded that abnormal SDH and COX histochemical activities in atrophic perifascicular fibers are characteristic of dermatomyositis. These abnormal staining characteristics could not be accounted for solely by myofiber atrophy, or by generalized abnormalities in histochemical staining. |
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Authors:
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Mohammed I Alhatou; John T Sladky; Omar Bagasra; Jonathan D Glass |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of molecular histology Volume: 35 ISSN: 1567-2379 ISO Abbreviation: J. Mol. Histol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-12-22 Completed Date: 2005-03-23 Revised Date: 2006-04-19 |
Medline Journal Info:
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Nlm Unique ID: 101193653 Medline TA: J Mol Histol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 615-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA. malhatou44@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Biopsy Child Child, Preschool Dermatomyositis / enzymology*, pathology* Electron Transport Complex IV / analysis Female Humans Male Middle Aged Mitochondria / enzymology*, pathology* Muscle, Skeletal / cytology, enzymology, pathology Succinate Dehydrogenase / analysis |
| Chemical | |
Reg. No./Substance:
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EC 1.3.99.1/Succinate Dehydrogenase; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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