Document Detail


Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology.
MedLine Citation:
PMID:  15614615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the work described in this paper was to evaluate mitochondrial abnormalities in perifascicular atrophic fibers in muscle biopsies from patients with dermatomyositis (DM). We localized cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemically in muscle biopsies of 12 patients with DM, and 12 control patients with neurogenic atrophy. These two histochemical techniques were also combined on single tissue sections in order to accentuate any COX-negative fibers. Eleven out of 12 patients (91.6%) with DM showed histochemical evidence of mitochondrial dysfunction in perifascicular distribution. Similar abnormalities in histochemical staining were not seen in comparably sized myofibers that were atrophic due to denervation. It is concluded that abnormal SDH and COX histochemical activities in atrophic perifascicular fibers are characteristic of dermatomyositis. These abnormal staining characteristics could not be accounted for solely by myofiber atrophy, or by generalized abnormalities in histochemical staining.
Authors:
Mohammed I Alhatou; John T Sladky; Omar Bagasra; Jonathan D Glass
Related Documents :
1524405 - Partial deletion 10p syndrome. report of two patients.
8186715 - Clinical features of oculopharyngeal muscular dystrophy among bukhara jews.
20496415 - A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immun...
2553875 - Lymphocytic beta-adrenergic receptors in x-linked muscular dystrophy.
19814775 - Is there any association between disturbed gastrointestinal visceromotor and sensory fu...
1296045 - Flow cytometric dna analysis of pleural effusions.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular histology     Volume:  35     ISSN:  1567-2379     ISO Abbreviation:  J. Mol. Histol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-12-22     Completed Date:  2005-03-23     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  615-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA. malhatou44@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy
Child
Child, Preschool
Dermatomyositis / enzymology*,  pathology*
Electron Transport Complex IV / analysis
Female
Humans
Male
Middle Aged
Mitochondria / enzymology*,  pathology*
Muscle, Skeletal / cytology,  enzymology,  pathology
Succinate Dehydrogenase / analysis
Chemical
Reg. No./Substance:
EC 1.3.99.1/Succinate Dehydrogenase; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Are histochemistry and cytochemistry 'Omics'?
Next Document:  Molecular morphology of neuronal apoptosis: analysis of caspase 3 activation during postnatal develo...