Document Detail

Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology.
MedLine Citation:
PMID:  15614615     Owner:  NLM     Status:  MEDLINE    
The objective of the work described in this paper was to evaluate mitochondrial abnormalities in perifascicular atrophic fibers in muscle biopsies from patients with dermatomyositis (DM). We localized cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemically in muscle biopsies of 12 patients with DM, and 12 control patients with neurogenic atrophy. These two histochemical techniques were also combined on single tissue sections in order to accentuate any COX-negative fibers. Eleven out of 12 patients (91.6%) with DM showed histochemical evidence of mitochondrial dysfunction in perifascicular distribution. Similar abnormalities in histochemical staining were not seen in comparably sized myofibers that were atrophic due to denervation. It is concluded that abnormal SDH and COX histochemical activities in atrophic perifascicular fibers are characteristic of dermatomyositis. These abnormal staining characteristics could not be accounted for solely by myofiber atrophy, or by generalized abnormalities in histochemical staining.
Mohammed I Alhatou; John T Sladky; Omar Bagasra; Jonathan D Glass
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular histology     Volume:  35     ISSN:  1567-2379     ISO Abbreviation:  J. Mol. Histol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-12-22     Completed Date:  2005-03-23     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  615-9     Citation Subset:  IM    
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Dermatomyositis / enzymology*,  pathology*
Electron Transport Complex IV / analysis
Middle Aged
Mitochondria / enzymology*,  pathology*
Muscle, Skeletal / cytology,  enzymology,  pathology
Succinate Dehydrogenase / analysis
Reg. No./Substance:
EC Dehydrogenase; EC Transport Complex IV

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