| Mitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents. | |
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MedLine Citation:
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PMID: 15602126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lipodystrophy is now widely described in HIV infected patients under antiretroviral regimen with important psychological impact. But physiopathology of loss of fat mass is still debated and the role of mitochondrial impairment is not clearly defined. OBJECTIVE: To correlate clinical lipoatrophy (LA) in HIV patients with long-term treatment by nucleoside reverse transcriptase inhibitors (NRTIs) and muscular impairment related to mitochondrial dysfunction. METHODS: Ten consecutive patients with clinical LA and 10 nonlipodystrophic (NLD) individuals on antiretroviral therapy were included. Patients underwent the following investigations: dual-energy x-ray absorptiometry (DEXA) scanning and lactate kinetics during standardized exercise. The mitochondrial respiratory complex activity (III and IV) and histoenzymatic abnormalities (classified as none, mild, or severe) were evaluated on muscle tissue obtained by biopsy in deltoid muscle. RESULTS: Mean NRTI exposure was longer in the LA group than in the NLD group (81 +/- 30 months vs. 59 +/- 15 months), but mean protease inhibitor exposure was identical in both groups. Mean fat mass distribution for leg in the LA and NLD groups was 860 +/- 381 g versus 1895 +/- 999 g, respectively. The lactic acidosis threshold during exercise was reached in the LA group at lower workloads (mean: 45 +/- 17 W in the LA group vs. 68 +/- 11 W in the NLD group), and maximum power output exercise was restricted in LA patients (mean: 115 +/- 30 W vs. 153 +/- 28 W). Total complex activities in muscular tissue were lower in LA patients: the median (range) for complex III was 67 (1-128) versus 112 (28-143), and the median (range) for complex IV was 28 (1-70) versus 42 (1-75). Six patients had severe histoenzymatic abnormalities in the LA group versus none in the NLD group. CONCLUSION: Clinical LA, confirmed by DEXA, in long-term NRTI-treated patients was associated with muscular mitochondrial dysfunction as shown by rapid lactic acidemia increase, impairment of respiratory chain activity for complexes III and IV, and mitochondrial histoenzymatic abnormalities. |
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Authors:
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Jean-Marc Chapplain; Jocelyne Beillot; Jean-Marc Begue; Faouzi Souala; Cécile Bouvier; Cédric Arvieux; Pierre Tattevin; Mathieu Dupont; Françoise Chapon; Régis Duvauferrier; Jean-Pierre Hespel; Pierre Rochcongar; Christian Michelet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 37 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-16 Completed Date: 2006-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 1477-88 Citation Subset: IM; X |
Affiliation:
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Infectious Diseases Department, Rennes University Hospital, Rennes, France. jean-marc.chapplain@chu-rennes.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Acidosis, Lactic / blood, chemically induced* Adult Aged Aged, 80 and over Anti-Retroviral Agents / administration & dosage, adverse effects* HIV Infections / complications, drug therapy*, metabolism Humans Lipodystrophy / chemically induced* Middle Aged Mitochondria, Muscle / drug effects Mitochondrial Diseases / complications* Reverse Transcriptase Inhibitors / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Retroviral Agents; 0/Reverse Transcriptase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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