Document Detail

Mitochondrial morphology transitions and functions: implications for retrograde signaling?
MedLine Citation:
PMID:  23364527     Owner:  NLM     Status:  MEDLINE    
In response to cellular and environmental stresses, mitochondria undergo morphology transitions regulated by dynamic processes of membrane fusion and fission. These events of mitochondrial dynamics are central regulators of cellular activity, but the mechanisms linking mitochondrial shape to cell function remain unclear. One possibility evaluated in this review is that mitochondrial morphological transitions (from elongated to fragmented, and vice-versa) directly modify canonical aspects of the organelle's function, including susceptibility to mitochondrial permeability transition, respiratory properties of the electron transport chain, and reactive oxygen species production. Because outputs derived from mitochondrial metabolism are linked to defined cellular signaling pathways, fusion/fission morphology transitions could regulate mitochondrial function and retrograde signaling. This is hypothesized to provide a dynamic interface between the cell, its genome, and the fluctuating metabolic environment.
Martin Picard; Orian S Shirihai; Benoit J Gentil; Yan Burelle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-30
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  304     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-05-08     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R393-406     Citation Subset:  IM    
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MeSH Terms
Membrane Fusion
Mitochondria / metabolism,  ultrastructure*
Mitochondrial Membranes / metabolism,  ultrastructure*
Mitochondrial Proteins / metabolism*
Reactive Oxygen Species / metabolism
Signal Transduction / physiology*
Grant Support
86725//Canadian Institutes of Health Research; R01 DK035914/DK/NIDDK NIH HHS; R01 DK056690/DK/NIDDK NIH HHS; R01 DK074778/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Mitochondrial Proteins; 0/Reactive Oxygen Species

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