Document Detail


Mitochondrial Fatty Acid Oxidation Alterations in Heart Failure, Ischemic Heart Disease, and Diabetic Cardiomyopathy.
MedLine Citation:
PMID:  24147975     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischemic heart disease and diabetic cardiomyopathies, changes in cardiac mitochondrial energy metabolism contribute to contractile dysfunction and to a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac fatty acid oxidation rates and an uncoupling of glycolysis from glucose oxidation. In heart failure overall mitochondrial oxidative metabolism can be impaired, while in ischemic heart disease energy production is impaired due to a limitation of oxygen supply. In both of these conditions, residual mitochondrial fatty acid oxidation dominates over mitochondrial glucose oxidation. In diabetes the ratio of cardiac fatty acid oxidation to glucose oxidation also increases, although primarily due to an increase in fatty acid oxidation and an inhibition of glucose oxidation. Recent evidence suggests that therapeutically regulating cardiac energy metabolism by reducing fatty acid oxidation and/or increasing glucose oxidation can improve cardiac function of the ischemic heart, the failing heart, and in diabetic cardiomyopathies. In this article we review the cardiac mitochondrial energy metabolic changes that occur in these forms of heart disease, what role alterations in mitochondrial fatty acid oxidation have in contributing to cardiac dysfunction, and the potential for targeting fatty acid oxidation to treat these forms of heart disease.
Authors:
N Fillmore; J Mori; G D Lopaschuk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-21
Journal Detail:
Title:  British journal of pharmacology     Volume:  -     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.
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