| Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure. | |
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MedLine Citation:
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PMID: 21820793 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases. Full English text available from: www.revespcardiol.org. |
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Authors:
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Jovan Kuzmicic; Andrea Del Campo; Camila López-Crisosto; Pablo E Morales; Christian Pennanen; Roberto Bravo-Sagua; Jonathan Hechenleitner; Ramiro Zepeda; Pablo F Castro; Hugo E Verdejo; Valentina Parra; Mario Chiong; Sergio Lavandero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-4 |
Journal Detail:
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Title: Revista espanola de cardiologia Volume: - ISSN: 1579-2242 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404277 Medline TA: Rev Esp Cardiol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile. |
Vernacular Title:
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Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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