| Mitochondrial Drug Target in Cell Death and Cancer. | |
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MedLine Citation:
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PMID: 21718250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cells. The present review is focused in the different experimental and therapeutic cancer strategies addressed to either target mitochondria directly, or use mitochondria as mediators of apoptosis. While the first group includes drugs that act on glycolysis, β-oxidation, electron transport chain, mitochondrial permeability and the Bcl-2/IAP family protein, the second one consists of those drugs that cause cell death through the intrinsic apoptosis pathway by promoting ROS generation or by modulating mitochondrial protein involved in apoptosis induction. |
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Authors:
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Gustavo Ferrín; Clara I Linares; Jordi Muntané |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-30 |
Journal Detail:
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Title: Current pharmaceutical design Volume: - ISSN: 1873-4286 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Unidad de Investigación, Hospital Universitario Reina Sofía, Av. Menéndez Pidal s/n, E-14004 Córdoba, Spain. jordi.muntane.exts@juntadeandalucia.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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