Document Detail

Mitochondrial division in rat cardiomyocytes: an electron microscope study.
MedLine Citation:
PMID:  22753088     Owner:  NLM     Status:  MEDLINE    
In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves "pinching," in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown.
Hisashi Fujioka; Bernard Tandler; Charles L Hoppel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-02
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  295     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2013-06-10     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1455-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Electron Microscopy Facility and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Cell Division / physiology*
Microscopy, Electron / methods
Mitochondria, Heart / physiology*,  ultrastructure*
Myocytes, Cardiac / physiology*,  ultrastructure*
Rats, Inbred BN
Rats, Inbred F344
Grant Support
P01 AG015885/AG/NIA NIH HHS; P01 AG015885/AG/NIA NIH HHS

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