Document Detail

Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women.
MedLine Citation:
PMID:  21292039     Owner:  NLM     Status:  Publisher    
Several genetic factors have been found to be associated with recurrent pregnancy loss (RPL). However, not many attempts have been made to associate the mitochondrial DNA (mtDNA) variations with RPL. Therefore, we have analysed the complete mtDNA of 100 women with RPL and 12 aborted fetal tissues. Our analysis revealed a total of 681 variations, most of which were in NADH Dehydrogenase (ND) genes that encode mitochondrial enzyme Complex I. Presence of T4216C variation (ND1 gene) in 9% of the RPL women and several pathogenic, and novel mutations suggests the role of mtDNA variations in RPL.
Ayyasamy Vanniarajan; Periyasamy Govindaraj; S Justin Carlus; Meka Aruna; P Aruna; Ajay Kumar; Richard Issac Jayakar; Anath C Lionel; Sandeep Gupta; Lakshmi Rao; Nalini J Gupta; Baidyanath Chakravarthy; Mamatha Deenadayal; Kamala Selvaraj; Sadaranga Andal; B Mohan Reddy; Lalji Singh; Kumarasamy Thangaraj
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-31
Journal Detail:
Title:  Mitochondrion     Volume:  -     ISSN:  1872-8278     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
Centre for Cellular and Molecular Biology (CSIR), Hyderabad, India.
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