Document Detail


Mitochondrial DNA variation in human metabolic rate and energy expenditure.
MedLine Citation:
PMID:  21586348     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
Authors:
Gregory J Tranah; Todd M Manini; Kurt K Lohman; Michael A Nalls; Stephen Kritchevsky; Anne B Newman; Tamara B Harris; Iva Miljkovic; Alessandro Biffi; Steven R Cummings; Yongmei Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  Mitochondrion     Volume:  -     ISSN:  1872-8278     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
California Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
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