Document Detail


Mitochondrial DNA variation in human metabolic rate and energy expenditure.
MedLine Citation:
PMID:  21586348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
Authors:
Gregory J Tranah; Todd M Manini; Kurt K Lohman; Michael A Nalls; Stephen Kritchevsky; Anne B Newman; Tamara B Harris; Iva Miljkovic; Alessandro Biffi; Steven R Cummings; Yongmei Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-05-09
Journal Detail:
Title:  Mitochondrion     Volume:  11     ISSN:  1872-8278     ISO Abbreviation:  Mitochondrion     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-01     Completed Date:  2012-02-22     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
African Americans
Aged
DNA, Mitochondrial / genetics*,  metabolism*
Energy Metabolism / genetics*
European Continental Ancestry Group
Female
Genetic Variation*
Haplotypes
Humans
Male
United States
Grant Support
ID/Acronym/Agency:
1R01AG032098-01A1/AG/NIA NIH HHS; 1R03AG032498-01/AG/NIA NIH HHS; HHSN268200782096C//PHS HHS; N01 AG062103/AG/NIA NIH HHS; N01 AG62101/AG/NIA NIH HHS; N01AG62103/AG/NIA NIH HHS; N01AG62106/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial
Comments/Corrections

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