| Mitochondrial DNA from colorectal cancer cells promotes the malignant phenotype of NIH3T3 cells. | |
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MedLine Citation:
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PMID: 18595746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the potential role of mitochondrial DNA (mtDNA) in colorectal carcinogenesis by constructing a eukaryotic expression vector of the mitochondrial D-loop gene from colorectal cancer cell SW480 and transfected NIH3T3 cells. The NIH3T3/SW480 cells exhibited a significantly increased growth rate and colony formation rate, and also had a decreased apoptotic rate. Polyploidy and aberrant chromosomes were detected in the NIH3T3/SW480 cells by chromosome karyotype analysis. Our results suggested that mtDNA from colorectal cancer cells promotes the malignant phenotype of NIH3T3 cells. Further study of the biological functions of NIH3T3/SW480 cells might be helpful in understanding the role of mtDNA in colorectal carcinogenesis. |
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Authors:
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Yan Li; Song Weibing; Hong Liu; Ji Hongli; Lai Zhuosheng; Wang Yadong; Xiao Bing; Fan Daiming |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-10 |
Journal Detail:
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Title: Cell biology international Volume: 32 ISSN: 1065-6995 ISO Abbreviation: Cell Biol. Int. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 979-83 Citation Subset: IM |
Affiliation:
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Department of Digestive Diseases, Nanfang Hospital, Southern Medical University, 692 Sheng Li Southern Road, Guangzhou, Guangdong Province 510515, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic* Chromosome Aberrations Colorectal Neoplasms / genetics* DNA, Mitochondrial / metabolism* Genetic Vectors Humans Mice NIH 3T3 Cells Transfection |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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