Document Detail


Mitochondrial DNA and ancient population growth.
MedLine Citation:
PMID:  9537924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, the study of mitochondrial DNA (mtDNA) variation has entered a new phase with an increasing emphasis on interpretations of demographic, rather than phylogenetic, history. Human mtDNA variation fits a "sudden expansion" model, where the human species expanded rapidly in size during the Late Pleistocene. This paper examines the sudden expansion model with the goal of partitioning total mtDNA diversity in contemporary populations into two components--diversity that existed prior to the population expansion and diversity that arose after the expansion. A method is developed for estimating these components. Analysis of mtDNA diversity within selected human populations shows that 64-80% of mtDNA diversity in contemporary populations arose after the expansion, a consequence of a high mutation rate relative to the number of generations since expansion. The basic model is extended to two components of excess diversity in sub-Saharan Africa--differences in population size before the expansion and differences in the timing of expansion. Results suggest that excess sub-Saharan African mtDNA diversity is due to the combined effects of the sub-Saharan African population being larger in size prior to the expansion and expanding earlier.
Authors:
J H Relethford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physical anthropology     Volume:  105     ISSN:  0002-9483     ISO Abbreviation:  Am. J. Phys. Anthropol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0400654     Medline TA:  Am J Phys Anthropol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Anthropology, State University of New York College at Oneonta, 13820, USA. relethjh@oneonta.edu
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MeSH Terms
Descriptor/Qualifier:
Anthropology, Physical*
DNA, Mitochondrial / genetics*
Evolution
Genetic Variation*
Humans
Models, Theoretical
Population Density*
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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