Document Detail


Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes.
MedLine Citation:
PMID:  15886711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences in ACTN3 (alpha-actinin 3) genotypes have been reported among endurance and power athletes. Elite athletic performance in endurance sports should also depend on mitochondrial oxidative phosphorylation (OXPHOS) that produces ATP for muscle metabolism. We determined mitochondrial DNA (mtDNA) and ACTN3 genotypes in Finnish elite endurance (n = 52) and sprint (n = 89) athletes, and found that the frequencies of mtDNA haplogroups differed significantly between the two groups. Most notably, none of the endurance athletes belonged to haplogroup K or subhaplogroup J2, both of which have previously been associated with longevity. The frequency of ACTN3 XX genotype was higher and that of RR was lower among Finnish endurance athletes, and, in addition, none of the top Finnish sprinters had the XX genotype. Lack of mtDNA haplogroup K and subhaplogroup J2 among elite endurance athletes suggests that these haplogroups are 'uncoupling genomes'. Such genomes should not be beneficial to endurance-type athletic performance but should be beneficial to longevity, since uncoupling of OXPHOS reduces the production of ATP, reduces the release of reactive oxygen species and generates heat.
Authors:
Anna-Kaisa Niemi; Kari Majamaa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  13     ISSN:  1018-4813     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-12-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  965-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Actinin / genetics*
DNA, Mitochondrial*
Female
Finland / ethnology
Genetic Variation
Genetics, Population
Genotype
Haplotypes
Humans
Male
Physical Endurance
Polymorphism, Single Nucleotide
Track and Field / physiology*
Chemical
Reg. No./Substance:
0/ACTN3 protein, human; 0/DNA, Mitochondrial; 11003-00-2/Actinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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