| Mitochondria, telomeres and cell senescence. | |
| | |
MedLine Citation:
|
PMID: 15963673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The accumulation of oxidative damage is one of the most widely accepted causes of ageing. Mitochondrial dysfunction, in particular damage to the mitochondrial DNA has been hypothesised, more than thirty years ago, as responsible for increased production of reactive oxygen species (ROS) and, thus, as one possible causal factor for ageing. There is now a wealth of data that supports this hypothesis, which is mostly derived from models considering the ageing of post-mitotic or slowly dividing cells in vivo. One major cellular model of ageing, however, is replicative senescence, the irreversible loss of division potential of somatic cells after a more or less constant number of cell divisions. Not much data exists concerning the role of mitochondria in this model. Here, we review evidence supporting an involvement of mitochondria in replicative senescence and a possible link to telomere shortening. |
| | |
Authors:
|
João F Passos; Thomas von Zglinicki |
Related Documents
:
|
14585993 - Human heterochromatin protein 1 isoforms hp1(hsalpha) and hp1(hsbeta) interfere with ht... 20175753 - Immortalization of bovine mammary epithelial cells alone by human telomerase reverse tr... 6799493 - Timed action of the gene products required for septum formation in the cell cycle of ba... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Experimental gerontology Volume: 40 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-07-01 Completed Date: 2006-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
|
Languages: eng Pagination: 466-72 Citation Subset: IM |
Affiliation:
|
Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle NE4 6BE, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Aging
/
physiology* Cell Division / physiology Cell Nucleus / physiology DNA / physiology DNA, Mitochondrial / physiology Fibroblasts / physiology Free Radicals / metabolism Humans Mitochondria / physiology* Models, Biological Oxidative Stress / physiology Reactive Oxygen Species / metabolism Telomere / physiology* Uncoupling Agents / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Mitochondrial; 0/Free Radicals; 0/Reactive Oxygen Species; 0/Uncoupling Agents; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus mu...
Next Document: Neurofibromatosis type 1: diffusion weighted imaging findings of brain.