Document Detail

Mitochondria and neuroplasticity.
MedLine Citation:
PMID:  20957078     Owner:  NLM     Status:  MEDLINE    
The production of neurons from neural progenitor cells, the growth of axons and dendrites and the formation and reorganization of synapses are examples of neuroplasticity. These processes are regulated by cell-autonomous and intercellular (paracrine and endocrine) programs that mediate responses of neural cells to environmental input. Mitochondria are highly mobile and move within and between subcellular compartments involved in neuroplasticity (synaptic terminals, dendrites, cell body and the axon). By generating energy (ATP and NAD(+)), and regulating subcellular Ca(2+) and redox homoeostasis, mitochondria may play important roles in controlling fundamental processes in neuroplasticity, including neural differentiation, neurite outgrowth, neurotransmitter release and dendritic remodelling. Particularly intriguing is emerging data suggesting that mitochondria emit molecular signals (e.g. reactive oxygen species, proteins and lipid mediators) that can act locally or travel to distant targets including the nucleus. Disturbances in mitochondrial functions and signalling may play roles in impaired neuroplasticity and neuronal degeneration in Alzheimer's disease, Parkinson's disease, psychiatric disorders and stroke.
Aiwu Cheng; Yan Hou; Mark P Mattson
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-04
Journal Detail:
Title:  ASN neuro     Volume:  2     ISSN:  1759-0914     ISO Abbreviation:  ASN Neuro     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-12-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101507115     Medline TA:  ASN Neuro     Country:  Unknown    
Other Details:
Languages:  eng     Pagination:  e00045     Citation Subset:  IM    
Laboratory of Neurosciences, National Institute of Aging Intramural Research Program, Baltimore, MD 21224, U.S.A.
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MeSH Terms
Alzheimer Disease / metabolism,  pathology
Mitochondria / metabolism*,  pathology,  physiology
Neurogenesis / physiology
Neuronal Plasticity / physiology*
Neurons / cytology,  metabolism*,  pathology
Parkinson Disease / metabolism,  pathology
Synaptic Transmission / physiology

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