Document Detail


Mitochondria in heart failure.
MedLine Citation:
PMID:  20668004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review focuses on the evidence accumulated in humans and animal models to the effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria are the primary source of energy in the form of adenosine triphosphate that fuels the contractile apparatus, and are thus essential for the pumping activity of the heart. We evaluate changes in mitochondrial morphology and alterations in the main components of mitochondrial energetics, such as substrate utilization and oxidative phosphorylation coupled with the level of respirasomes, in the context of their contribution to the chronic energy deficit and mechanical dysfunction in HF.
Authors:
Mariana G Rosca; Charles L Hoppel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-07-28
Journal Detail:
Title:  Cardiovascular research     Volume:  88     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2011-01-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-50     Citation Subset:  IM    
Affiliation:
Center for Mitochondrial Diseases, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Energy Metabolism*
Heart Failure / metabolism*,  pathology,  physiopathology
Humans
Mitochondria, Heart / metabolism*,  pathology
Myocardial Contraction*
Myocardium / metabolism*,  pathology
Signal Transduction
Grant Support
ID/Acronym/Agency:
P01 HL074237/HL/NHLBI NIH HHS
Comments/Corrections

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