| Mitochondria in heart failure. | |
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MedLine Citation:
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PMID: 20668004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review focuses on the evidence accumulated in humans and animal models to the effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria are the primary source of energy in the form of adenosine triphosphate that fuels the contractile apparatus, and are thus essential for the pumping activity of the heart. We evaluate changes in mitochondrial morphology and alterations in the main components of mitochondrial energetics, such as substrate utilization and oxidative phosphorylation coupled with the level of respirasomes, in the context of their contribution to the chronic energy deficit and mechanical dysfunction in HF. |
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Authors:
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Mariana G Rosca; Charles L Hoppel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-07-28 |
Journal Detail:
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Title: Cardiovascular research Volume: 88 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2011-01-11 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 40-50 Citation Subset: IM |
Affiliation:
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Center for Mitochondrial Diseases, Case Western Reserve University, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Energy Metabolism* Heart Failure / metabolism*, pathology, physiopathology Humans Mitochondria, Heart / metabolism*, pathology Myocardial Contraction* Myocardium / metabolism*, pathology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL074237/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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