Document Detail

Mitochondria-dependent apoptosis in yeast.
MedLine Citation:
PMID:  18406358     Owner:  NLM     Status:  MEDLINE    
Mitochondrial involvement in yeast apoptosis is probably the most unifying feature in the field. Reports proposing a role for mitochondria in yeast apoptosis present evidence ranging from the simple observation of ROS accumulation in the cell to the identification of mitochondrial proteins mediating cell death. Although yeast is unarguably a simple model it reveals an elaborate regulation of the death process involving distinct proteins and most likely different pathways, depending on the insult, growth conditions and cell metabolism. This complexity may be due to the interplay between the death pathways and the major signalling routes in the cell, contributing to a whole integrated response. The elucidation of these pathways in yeast has been a valuable help in understanding the intricate mechanisms of cell death in higher eukaryotes, and of severe human diseases associated with mitochondria-dependent apoptosis. In addition, the absence of obvious orthologues of mammalian apoptotic regulators, namely of the Bcl-2 family, favours the use of yeast to assess the function of such proteins. In conclusion, yeast with its distinctive ability to survive without respiration-competent mitochondria is a powerful model to study the involvement of mitochondria and mitochondria interacting proteins in cell death.
C Pereira; R D Silva; L Saraiva; B Johansson; M J Sousa; M Côrte-Real
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-25
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1783     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1286-302     Citation Subset:  IM    
Departamento de Biologia-Centro de Biologia, Universidade do Minho, Campus de Gualtar, Braga, Portugal.
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MeSH Terms
Apoptosis / physiology*
Apoptosis Regulatory Proteins / metabolism*
Mitochondria / metabolism*
Mitochondrial Membranes / metabolism*
Mitochondrial Proteins / metabolism*
Signal Transduction
Yeasts / cytology,  physiology*
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Mitochondrial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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