Document Detail


Mitochondria-dependent apoptosis in yeast.
MedLine Citation:
PMID:  18406358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondrial involvement in yeast apoptosis is probably the most unifying feature in the field. Reports proposing a role for mitochondria in yeast apoptosis present evidence ranging from the simple observation of ROS accumulation in the cell to the identification of mitochondrial proteins mediating cell death. Although yeast is unarguably a simple model it reveals an elaborate regulation of the death process involving distinct proteins and most likely different pathways, depending on the insult, growth conditions and cell metabolism. This complexity may be due to the interplay between the death pathways and the major signalling routes in the cell, contributing to a whole integrated response. The elucidation of these pathways in yeast has been a valuable help in understanding the intricate mechanisms of cell death in higher eukaryotes, and of severe human diseases associated with mitochondria-dependent apoptosis. In addition, the absence of obvious orthologues of mammalian apoptotic regulators, namely of the Bcl-2 family, favours the use of yeast to assess the function of such proteins. In conclusion, yeast with its distinctive ability to survive without respiration-competent mitochondria is a powerful model to study the involvement of mitochondria and mitochondria interacting proteins in cell death.
Authors:
C Pereira; R D Silva; L Saraiva; B Johansson; M J Sousa; M Côrte-Real
Related Documents :
21343308 - Heparan sulfate modification of the transmembrane receptor cd47 is necessary for inhibi...
12675848 - Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and...
3125228 - Energy thresholds that determine membrane integrity and injury in a renal epithelial ce...
18442358 - Endosomal compartment contributes to the propagation of cd95/fas-mediated signals in ty...
23936128 - Cep63 and cep152 cooperate to ensure centriole duplication.
9284818 - Monoclonality of smooth muscle cells in human atherosclerosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-25
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1783     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1286-302     Citation Subset:  IM    
Affiliation:
Departamento de Biologia-Centro de Biologia, Universidade do Minho, Campus de Gualtar, Braga, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apoptosis / physiology*
Apoptosis Regulatory Proteins / metabolism*
Mitochondria / metabolism*
Mitochondrial Membranes / metabolism*
Mitochondrial Proteins / metabolism*
Signal Transduction
Yeasts / cytology,  physiology*
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Mitochondrial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential regulation of Krüppel-like factor family transcription factor expression in neonatal ra...
Next Document:  Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins.