| Mitochondria are sources of metabolic sink and arrhythmias. | |
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MedLine Citation:
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PMID: 21513732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitochondria have long been recognized for their central role in energy transduction and apoptosis. More recently, extensive work in multiple laboratories around the world has significantly extended the role of cardiac mitochondria from relatively static arbitrators of cell death and survival pathways to highly dynamic organelles that form interactive functional networks across cardiomyocytes. These coupled networks were shown to strongly affect cardiomyocyte responses to oxidative stress by modulating cell signaling pathways that strongly impact physiological properties. Of particular importance is the role of mitochondria in modulating key electrophysiological and calcium cycling properties in cardiomyocytes, either directly through activation of a myriad of mitochondrial ion channels or indirectly by affecting cell signaling cascades, ATP levels, and the over-all redox state of the cardiomyocyte. This important recognition has ushered a renewed interest in understanding, at a more fundamental level, the exact role that cardiac metabolism, in general and mitochondria, in particular, play in both health and disease. In this article, we provide an overview of recent advances in our growing understanding of the fundamental role that cardiac mitochondria play in the genesis of lethal arrhythmias. |
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Authors:
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Fadi G Akar; Brian O'Rourke |
Publication Detail:
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Type: Journal Article; Review Date: 2011-04-14 |
Journal Detail:
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Title: Pharmacology & therapeutics Volume: 131 ISSN: 1879-016X ISO Abbreviation: Pharmacol. Ther. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-11 Completed Date: 2011-12-07 Revised Date: 2012-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. fadi.akar@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / metabolism* Calcium / metabolism* Humans Mitochondria, Heart / metabolism* Myocytes, Cardiac / metabolism* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL091923-02/HL/NHLBI NIH HHS; R01 HL091923-04/HL/NHLBI NIH HHS; R21 HL097108-01A2/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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