| Mitochondria and aging in the vascular system. | |
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MedLine Citation:
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PMID: 20714704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review focuses on mitochondrial abnormalities that occur in the vasculature during aging and explores the link between mitochondrial oxidative stress, chronic low-grade vascular inflammation, increased rate of endothelial apoptosis, and development of vascular diseases in the elderly. Therapeutic strategies targeting the mitochondria for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the vasoprotective effects of caloric restriction, caloric restriction mimetics, the GH/IGF-1 axis, and mitochondria-targeted antioxidants. |
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Authors:
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Zoltan Ungvari; William E Sonntag; Anna Csiszar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-17 |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: 88 ISSN: 1432-1440 ISO Abbreviation: J. Mol. Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2011-01-13 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 1021-7 Citation Subset: IM |
Affiliation:
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Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Blood Vessels / metabolism* Endothelium / metabolism Humans Inflammation / metabolism Mitochondria / metabolism* Oxidative Stress Reactive Oxygen Species / metabolism Vascular Diseases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AG11370/AG/NIA NIH HHS; HL077256/HL/NHLBI NIH HHS; P01 AG011370/AG/NIA NIH HHS; P01 AG011370-16/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species |
| Comments/Corrections | |
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