| A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice. | |
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MedLine Citation:
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PMID: 20554905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective in this study was to determine whether a mitochondria-targeted vitamin E derivative (MitoVit E) would decrease oxidative stress and associated obesity by preventing a previously proposed aconitase inhibition cascade. Sixty-four mice were fed a high-fat (HF) diet for 5 wk. They were then switched to either a low-fat (LF) or a medium-fat (MF) diet and gavaged with MitoVit E (40 mg MitoVit E x kg body weight(-1)) or drug vehicle (10% ethanol in 0.9% NaCl solution) every other day for 5 wk. Epididymal fat weight, as well as liver lipid and remaining carcass lipid, were significantly lower in the MF group receiving MitoVit E (MF-E) than in the MF group receiving vehicle only (MF-C). Liver mitochondrial H(2)O(2) production and the protein carbonyl level were also significantly lower in MF-E than in MF-C mice. In contrast, none of the biochemical variables (aconitase activity, ATP and H(2)O(2) production, and protein carbonyl level) in the muscle mitochondria were modified by MitoVit E in either MF or LF groups. Expression of acetyl-CoA carboxylase and fatty acid synthase in both liver and adipose tissue of MF groups was not affected by MitoVit E. However, expression of carnitine palmitoyltransferase 1a in the liver and uncoupling protein 2 in adipose tissue were significantly enhanced by MitoVit E in both LF and MF groups. In conclusion, MitoVit E attenuates hepatic oxidative stress and inhibits fat deposition in mice but not through alleviation of the aconitase inhibition cascade. |
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Authors:
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Gaowei Mao; George A Kraus; Ikyon Kim; Michael E Spurlock; Theodore B Bailey; Qijing Zhang; Donald C Beitz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-06-16 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1425-31 Citation Subset: IM |
Affiliation:
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Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aconitate Hydratase
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antagonists & inhibitors,
genetics Adenosine Triphosphate / metabolism Adipose Tissue / anatomy & histology, metabolism* Animals Body Composition Body Weight Diet Dietary Fats / administration & dosage Eating Fatty Acid Synthetase Complex / genetics Gene Expression / drug effects Hydrogen Peroxide / metabolism Lipids / analysis Liver / chemistry, drug effects, metabolism* Male Mice Mice, Inbred C57BL Mitochondria, Liver / enzymology, metabolism Mitochondria, Muscle / enzymology, metabolism Muscle, Skeletal / ultrastructure Obesity / prevention & control Organ Size / drug effects Organophosphorus Compounds / administration & dosage, pharmacology* Oxidative Stress / drug effects* RNA, Messenger / analysis Ubiquinone / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipids; 0/MitoVit E; 0/Organophosphorus Compounds; 0/RNA, Messenger; 1339-63-5/Ubiquinone; 56-65-5/Adenosine Triphosphate; 7722-84-1/Hydrogen Peroxide; EC 4.2.1.3/Aconitate Hydratase; EC 6.-/Fatty Acid Synthetase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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