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Mitochondria DNA variation and increased oxidative damage in euthymic patients with bipolar disorder.
MedLine Citation:
PMID:  24447331     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To compare alterations of mitochondria DNA (mtDNA) copy number, single nucleotide polymorphisms (SNPs), and oxidative damage of mtDNA in clinically stable patients with bipolar I disorder (BD).
METHODS: Patients met DSM-IV diagnostic criteria for BD were recruited from the psychiatric outpatient clinic at Changhua Christian Hospital, Taiwan. They were clinically stable and their medications had not changed for at least the preceding two months. Exclusion criteria were substance-induced psychotic disorder, eating disorder, anxiety disorder or illicit substance abuse. Comparison subjects did not have any history of major psychiatric disorders and they were non-smokers. By analyzing peripheral blood leukocytes, copy number, SNPs and oxidative damage of mtDNA were compared between the two groups.
RESULTS: The median age of the subjects was 38 years and 41.5 years in comparison and BD group, respectively. Leukocyte mtDNA copy number of BD group was significantly lower than that of the comparison group (p<0.001). BD patients had significantly higher mitochondrial oxidative damage than the comparison group (6.1 vs 3.9, p<0.001). After generalized linear model adjusting with age, sex, smoking, family history, and psychotropic use, mtDNA copy number was still significantly lower in BD group (p<0.001). MtDNA oxidative damage was positively correlated with age (p=0.034), although mtDNA oxidative damage was similar between these two groups.
CONCLUSION: Possible involvement of oxidative stress and mitochondria in the pathophysiology of BD needs more large-scale studies. It is important that psychiatrists remain a high level of suspicion for mitochondrial dysfunction in patients with bipolar disorder.
Authors:
Cheng-Chen Chang; Shaw-Hwa Jou; Ta-Tsung Lin; Chin-San Liu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-22
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  -     ISSN:  1440-1819     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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