Document Detail


Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways.
MedLine Citation:
PMID:  14977177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two main intracellular apoptosis cascades, the receptor and the mitochondria pathway, have been identified. The mitochondrial pathway is controlled by the Bcl-2 proteins. This protein family contains members with either pro- or anti-apoptotic activity. When activated the pro-apoptotic multidomain proteins permeabilized the outer mitochondrial membrane, resulting in the release of proteins from the intermembrane space. Several proteins, including cytochrome c, Smac/DIABLO, HtrA2/Omi, endonuclease G and AIF, normally sequestered in the mitochondria induce or promote apoptosis once released into the cytosol. Although, apoptosis is an essential physiological process in multicellular organisms it is also involved in a wide range of pathological conditions.
Authors:
Bruno Antonsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  256-257     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-02-23     Completed Date:  2004-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-55     Citation Subset:  IM    
Affiliation:
Serono Pharmaceutical Research Institute, Geneva, Switzerland. bruno.antonsson@serono.com
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / physiology*
Caspases / metabolism
Humans
Mitochondria / physiology*
Proto-Oncogene Proteins c-bcl-2 / physiology*
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.-/Caspases

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