Document Detail

Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice.
MedLine Citation:
PMID:  24143048     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Consumption of green-leafy vegetables is being advocated beneficial for type 2 diabetes mellitus individuals possibly because they are cost effective source of potent biological antioxidants. This research analyzed various phytochemicals, free radicals scavenging antioxidant potentials and starch digesting enzymes inhibitory activities in fresh juice of nine green-leafy vegetables. Furthermore, this study also investigated influence of these vegetables juice on starch and glucose induced postprandial glycemic load.
MATERIALS AND METHODS: Phytochemical constituents, in vitro free radicals scavenging antioxidant and enzymes inhibitory activities were evaluated applying various reported methods. Post-prandial glycemic excursion was induced in rats pretreated with vegetables juice by oral administration of starch and glucose.
RESULTS: All the leafy vegetables juice displayed potent free radicals scavenging activities. Juice of amaranthus, rumex, palak and raphanus displayed potential anti-oxidative property by reducing H2O2 induced hemolysis in rats red blood cells RBCs. Ajwain and rumex juice showed pancreatic α-amylase inhibitory activity. Alternanthera, ajwain, methi, amaranthus and sowa leaves juice displayed intestinal α-glucosidase inhibitory activity. Juice of raphanus, ajwain and sowa significantly mitigated starch-induced postprandial glycemic load. Amaranthus leaves juice potently mitigated glucose-induced postprandial glycemic load and also reduced hemoglobin glycation induced by glucose in vitro.
CONCLUSIONS: This investigation finds that juice of leafy vegetables is potent source of biological antioxidants. In addition, juice of raphanus, ajwain and sowa leaves possess capacity to mitigate starch induced postprandial glycemic burden and amaranthus leaves' juice can reduce glucose induced postprandial glycemic excursion.
Ashok Kumar Tiwari; Atmakuri Lakshmana Jyothi; Vasantharao Brahma Tejeswini; Kuncha Madhusudana; Domati Anand Kumar; Amtul Zehra; Sachin Bharat Agawane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacognosy magazine     Volume:  9     ISSN:  0973-1296     ISO Abbreviation:  Pharmacogn Mag     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-21     Completed Date:  2013-10-21     Revised Date:  2013-10-23    
Medline Journal Info:
Nlm Unique ID:  101300403     Medline TA:  Pharmacogn Mag     Country:  India    
Other Details:
Languages:  eng     Pagination:  S66-73     Citation Subset:  -    
Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
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