Document Detail

Mitigation of hearing loss from semi-circular canal transection in pseudomonas otitis media with ciprofloxacin-dexamethasone irrigation.
MedLine Citation:
PMID:  16436999     Owner:  NLM     Status:  MEDLINE    
HYPOTHESIS: Irrigation of the mastoid with a quinolone antibiotic-steroid solution may mitigate hearing loss caused by iatrogenic semicircular canal injury in the presence of Pseudomonas aeruginosa (PA) otitis media (OM). BACKGROUND: Studies have shown the cochlea to be more vulnerable to semicircular canal transection (SCT)-related hearing loss in the presence of PA OM. Prophylactic systemic antibiotics and steroids may decrease this hearing loss, but SCT is usually not planned. The aim of this study was to determine if irrigation with ciprofloxacin-dexamethasone (cipro-dex) could improve hearing outcomes following SCT in PA OM. METHODS: PA OM was induced in 28 animals. After three to five days, unilateral SCT was performed in each animal, with sham SCT on the contralateral ear. At surgery, half of the animals (n = 14) underwent irrigation of the both mastoid bullae with cipro-dex; the second group of animals (n = 14) underwent irrigation of the bullae with sterile saline. Auditory thresholds were obtained immediately prior to SCT and 7-10 days after SCT. RESULTS: SCT ears treated with cipro-dex showed a mean click threshold improvement of 4.6 dB from pre-transection to 7-10 days post-transection, whereas thresholds in the SCT ears treated with saline worsened by 7.5 dB (p = 0.15). CONCLUSION: Irrigation of the guinea pig bulla with cipro-dex following SCT in the setting of PA OM appears safe and may yield beneficial effects on hearing.
Sarah E Shefelbine; Linda J Young; Patrick J Antonelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  27     ISSN:  1531-7129     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-26     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Department of Otolaryngology, University of Florida, Gainesville, Florida 32610-0264, USA.
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MeSH Terms
Anti-Infective Agents / administration & dosage,  therapeutic use*
Auditory Threshold / drug effects
Ciprofloxacin / administration & dosage,  therapeutic use
Dexamethasone / administration & dosage,  therapeutic use
Glucocorticoids / administration & dosage,  therapeutic use*
Guinea Pigs
Hearing Loss, Sensorineural / drug therapy*,  etiology
Otitis Media / microbiology,  surgery*
Postoperative Care
Postoperative Complications / drug therapy,  etiology
Pseudomonas Infections / surgery*
Pseudomonas aeruginosa / pathogenicity
Semicircular Canals / injuries,  surgery*
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Glucocorticoids; 50-02-2/Dexamethasone; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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