| Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia. | |
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MedLine Citation:
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PMID: 11199946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies indicate an association between human leukocyte antigens (HLA) and clozapine-induced agranulocytosis. The authors have previously reported a significantly increased frequency of HLA-A1 among patients with schizophrenia who do not respond to conventional drugs, but do respond to clozapine treatment. In this study, the authors addressed the question of whether the same association is found in patients developing granulocytopenia or agranulocytosis. The frequency of the HLA-A1 allele in patients with clozapine-induced agranulocytosis or granulocytopenia was low (11.5%), whereas HLA-A1 was associated with a good therapeutic response to clozapine at an allele frequency of 58%. The frequency of HLA-A1 is 20% in the Finnish population. These results suggest that HLA-A1 may predict a good therapeutic outcome and a low risk of agranulocytosis and, thus, enable defining a subgroup of patients with schizophrenia in whom clozapine treatment could be started early to stop the disease from progressing. |
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Authors:
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L Lahdelma; A Ahokas; L C Andersson; J Suvisaari; I Hovatta; M O Huttunen; S Koskimies |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 21 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-01-25 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 4-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Haartman Institute, University of Helsinki, Finland. liisa.lahdelma@megabaud.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Agranulocytosis / chemically induced, genetics* Antipsychotic Agents / adverse effects, therapeutic use* Clozapine / adverse effects, therapeutic use* Female Gene Frequency Genetic Predisposition to Disease HLA-A1 Antigen / genetics* Humans Male Middle Aged Prognosis Risk Factors Schizophrenia / complications, drug therapy, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/HLA-A1 Antigen; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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