| Misuse of buprenorphine maintenance treatment since introduction of its generic forms: OPPIDUM survey. | |
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MedLine Citation:
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PMID: 22109894 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The purpose of the study was to compare, using data from Observation of Illicit Psychotropic Substances or Non-medical Used Medications (OPPIDUM) surveys, first, the profile of buprenorphine users and their modalities of buprenorphine use from 2006 to 2008 and, second, two subgroups: brand-name and generic buprenorphine users in 2008. METHODS: OPPIDUM is an annual, nationwide, multicentric, cross-sectional survey, including buprenorphine users followed in specialised centres dedicated to drug dependence. The evolution of the profile during three consecutive years (2006, 2007 and 2008) was analysed using Cochran-Armitage test for trend. A multivariate regression analysis was used to identify the factors associated with the use of generic compared with brand-name buprenorphine in 2008. RESULTS: In OPPIDUM, 1311 individuals used buprenorphine in 2006, 1688 in 2007 and 1696 in 2008. The proportion of users of generic buprenorphine increased from 4.2% in 2006 to 31.7% in 2008. From 2006 to 2008, a decrease in intravenous use and higher than recommended dosage, with an increase in occupation, have been observed. According to the multivariate analysis, factors associated with being generic buprenorphine user compared with brand-name buprenorphine user in 2008 were younger age, more education, absence of use of alcohol with buprenorphine, absence of heroin and/or cocaine use and absence of nasal route for buprenorphine. CONCLUSION: Three years after the launch of the buprenorphine generic, the health professionals' and buprenorphine users' perception of generic can still change. Additionally, the long-term impact of generic medications with abuse potential has not yet been studied. Thus, continued monitoring of buprenorphine is needed. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Sandra Nordmann; Elisabeth Frauger; Vanessa Pauly; Veronica Orléans; Vincent Pradel; Michel Mallaret; Xavier Thirion; Joëlle Micallef |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: Pharmacoepidemiology and drug safety Volume: - ISSN: 1099-1557 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208369 Medline TA: Pharmacoepidemiol Drug Saf Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Centre d'Evaluation et d'Information de la Pharmacodépendance-Addictovigilance PACA-Corse, Pharmacologie Clinique, Hôpital Timone, Marseille & Institut des Neurosciences Cognitives de la Méditerranée, Faculté de médecine, UMR 6193-CNRS, Marseille, France. |
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