Document Detail


Missing: a diagnostic technique to enumerate antigen-specific T cells.
MedLine Citation:
PMID:  22137827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T lymphocytes are responsible for immune responses against pathogens, immune surveillance against cancer and maintenance of tolerance to self. While techniques available to detect antigen-specific T cells have been well described, there is a missing technique in our repertoire. While fluorescent multimers can be used for limited research applications, there is no existing technique suitable for detection of antigen-specific T cells in a diagnostic setting. The absence of such a technology has inhibited the search for "correlates of protection" against infectious, autoimmune or malignant disease. This critical review of existing methods will highlight the limitations of the data on which our current understanding of the immune system is based, in an effort to stimulate development of improved techniques.
Authors:
Melinda Shelley Suchard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-12-03
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  83     ISSN:  1879-0461     ISO Abbreviation:  Crit. Rev. Oncol. Hematol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-11-20     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  276-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Molecular Medicine and Haematology, National Health Laboratory Service, Faculty of Health Sciences, University of Witwatersrand, 7 York Road Parktown, Johannesburg 2192, South Africa. Melinda.suchard@nhls.ac.za
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / analysis,  immunology
Antigens / analysis*,  immunology
Humans
Immunologic Tests / methods*
T-Lymphocytes / cytology,  immunology*
Grant Support
ID/Acronym/Agency:
1U2RTW007373//PHS HHS; 5U2R TW007370/TW/FIC NIH HHS; U2R TW007370-03/TW/FIC NIH HHS; U2R TW007370-04/TW/FIC NIH HHS; U2R TW007370-05/TW/FIC NIH HHS; U2R TW007373-03/TW/FIC NIH HHS; U2R TW007373-04/TW/FIC NIH HHS; U2R TW007373-05/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens
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