Document Detail

Missed opportunities: ALT and anti-HBc as surrogate tests for hepatitis.
MedLine Citation:
PMID:  9604794     Owner:  NLM     Status:  MEDLINE    
ALT and anti-HBc came into use in the US as surrogate tests for non-A, non-B hepatitis by 1986-1987, generally using cutoffs at 50-60 IU/L. We studied the usefulness of anti-HBc, and of ALT at different cutoffs as surrogate tests for hepatitis C virus, recording and analyzing the ALT, anti-HBc, HBsAg, and RIBA results of 175 non-autologous blood donations in 1993 and 1994 that had positive second generation screening tests for anti-HCV. ALT levels of 1014 blood donations also were studied. Only 93 of 175 anti-HCV-positive donations were RIBA positive. Of these, anti-HBc would have excluded 23%, an ALT cutoff at 60 IU/L would have excluded 42% and an ALT cutoff at 40 IU/L would have excluded 70% (plus 5.6% of all donations). Both tests together would have been better than either alone. No tests for HBsAg were positive. ALT and anti-HBc clearly were useful surrogate tests for hepatitis C. If they had been used sooner and with lower ALT cutoffs, many people would have avoided post-transfusion hepatitis in the years before anti-HCV testing was available.
R Bettigole; K A Shastri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicine     Volume:  28     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1997  
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
Department of Medicine, State University of New York at Buffalo, USA.
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MeSH Terms
Alanine Transaminase / blood*
Blood Donors*
Hematologic Tests*
Hepatitis / diagnosis*
Hepatitis B Antibodies / analysis*
Hepatitis B Core Antigens / immunology*
Immunoblotting / methods
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Core Antigens; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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