| Missed opportunities: ALT and anti-HBc as surrogate tests for hepatitis. | |
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MedLine Citation:
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PMID: 9604794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ALT and anti-HBc came into use in the US as surrogate tests for non-A, non-B hepatitis by 1986-1987, generally using cutoffs at 50-60 IU/L. We studied the usefulness of anti-HBc, and of ALT at different cutoffs as surrogate tests for hepatitis C virus, recording and analyzing the ALT, anti-HBc, HBsAg, and RIBA results of 175 non-autologous blood donations in 1993 and 1994 that had positive second generation screening tests for anti-HCV. ALT levels of 1014 blood donations also were studied. Only 93 of 175 anti-HCV-positive donations were RIBA positive. Of these, anti-HBc would have excluded 23%, an ALT cutoff at 60 IU/L would have excluded 42% and an ALT cutoff at 40 IU/L would have excluded 70% (plus 5.6% of all donations). Both tests together would have been better than either alone. No tests for HBsAg were positive. ALT and anti-HBc clearly were useful surrogate tests for hepatitis C. If they had been used sooner and with lower ALT cutoffs, many people would have avoided post-transfusion hepatitis in the years before anti-HCV testing was available. |
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Authors:
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R Bettigole; K A Shastri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicine Volume: 28 ISSN: 0025-7850 ISO Abbreviation: J Med Publication Date: 1997 |
Date Detail:
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Created Date: 1998-07-27 Completed Date: 1998-07-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505566 Medline TA: J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 363-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, State University of New York at Buffalo, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood* Blood Donors* Hematologic Tests* Hepatitis / diagnosis* Hepatitis B Antibodies / analysis* Hepatitis B Core Antigens / immunology* Humans Immunoblotting / methods |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis B Antibodies; 0/Hepatitis B Core Antigens; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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