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Misoprostol with or without letrozole pretreatment for termination of pregnancy: a randomized controlled trial.
MedLine Citation:
PMID:  21252745     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To compare the success rate and side effects of letrozole and misoprostol versus misoprostol alone for medical termination of early pregnancy.
METHODS: : Patients requesting termination of pregnancy up to 63 days of gestation were randomized into two groups. The letrozole group received letrozole 10 mg daily for 3 days followed by 800 micrograms of vaginal misoprostol, while the placebo group received placebo for 3 days followed by the same dosage of misoprostol. The complete abortion rate and the side effects profiles of the two groups were compared. The primary outcome measure was the complete abortion rate.
RESULTS: : A total of 168 women were recruited. The complete abortion rate of the letrozole group was significantly higher than that of the placebo group (86.9% compared with 72.6%, relative risk [RR] 1.20, 95% confidence interval [CI] 1.03-1.40). The complete abortion rate in gestations up to 49 days was significantly higher in the letrozole group than in the placebo group (93.3% compared with 78.7%, RR 1.19, 95% CI 1.002-1.40), while the corresponding rates for gestation between 50 and 63 days were not significantly different between the two groups. There were significantly fewer women complaining of vomiting in the letrozole group than those in the placebo group (8.3% compared with 19.0%, P=.043, RR 2.29, 95% CI 1.005-5.27).
CONCLUSION: : The use of letrozole and misoprostol is associated with a higher complete abortion rate.
Vivian Chi Yan Lee; Ernest Hung Yu Ng; William Shu Biu Yeung; Pak Chung Ho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  117     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  AIM; IM    
From the Department of Obstetrics and Gynecology, the University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
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