Document Detail

Misoprostol for termination of second trimester pregnancy in a scarred uterus.
MedLine Citation:
PMID:  16883447     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether Misoprostol for mid-trimester pregnancy interruption in women with a scarred uterus has any adverse effects compared with those without a scar. METHODS: During 5-year period from 2000-2004 at Queen Alia Military Hospital, Royal Medical Services, Amman, Jordan, a consecutive series of 520 women of 15-28 weeks of gestation who underwent termination of pregnancy were studied. Sixty-three patients had undergone at least previous one cesarean section and 457 served as control. Termination was undertaken using Misoprostol 400 ug vaginally as a starting dose followed by 200 ug vaginally every 6 hours, complications for each group were recorded. RESULTS: The induction to abortion time was not significantly different in both groups (p=0.16); the median dosage was almost the same (p=0.31). The rate of incomplete abortion was significantly higher in the study group than control 82% versus 60% and 11.5% versus 6.1% for bleeding of more than 500 cc, while the rate of other complications was almost the same. CONCLUSION: In the second trimester termination of pregnancy, the use of Misoprostol in women with previous single or multiple cesarean sections was not associated with excess complications.
Amal G Shammas; Murad D Momani
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  27     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-11-21     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1173-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Queen Alia Military Hospital, Royal Medical Services. Jordan, PO Box 962745, Amman 11196, Jordan.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use*
Abortion, Induced*
Cesarean Section* / adverse effects
Cicatrix / etiology
Misoprostol / therapeutic use*
Pregnancy Trimester, Second*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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