Document Detail

Misoprostol for term labor induction: A randomized controlled trial.
MedLine Citation:
PMID:  21482368     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: The aim of this study was to compare the efficacy of vaginal misoprostol with vaginal dinoprostone for term labor induction.
MATERIAL AND METHODS: It was a randomized controlled trial done in the Obstetrics Department, Shifa Community Health Centre, Shifa International Hospital (Teaching Hospital of Shifa College of Medicine, Islamabad). All pregnant women at term pregnancy coming for induction of labor were enrolled. 246 women fulfilled the inclusion criteria. Out of them 208 women consented to be part of the study. These women were then randomized to receive either Treatment A (vaginal misoprostol) or Treatment B (vaginal dinoprostone). Data were completed for 200 women. These included induction labor and induction-delivery interval, fetal and maternal complications, and baby apgar score.
RESULTS: Out of 200 women in the study, 100 were in Group A and 100 in Group B. Labor commenced in a mean of 6.67hours (±3.63) in Group A whereas it took a mean of 8.41hours (±5.13) in Group B (p=0.00). Actual induction to delivery (of the baby) interval was a mean of 11.68hours (±4.55) for misoprostol and 15.37hours (±5.30) for dinoprostone group (p=0.00). There were no cases of uterine rupture in both groups; however, there were 10 cases of uterine hyperstimulation in Group A and 4 in Group B (p=0.09).
CONCLUSIONS: It is time to re-evaluate the role of misoprostol for term labor induction. It is an efficacious and cost-effective alternative to the presently licensed treatment.
Gulshan A Saeed; Shazia Fakhar; Nadia Nisar; Ali Yawar Alam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  50     ISSN:  1875-6263     ISO Abbreviation:  Taiwan J Obstet Gynecol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Obstetrics and Gynecology, Shifa College of Medicine, H-8/4 Islamabad, Pakistan.
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