| Misoprostol moistened with acetic acid or saline for second trimester pregnancy termination: a randomized prospective double-blind trial. | |
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MedLine Citation:
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PMID: 16037107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study was conducted to evaluate the efficacy and side effects of a new regimen of 800 microg misoprostol administered intravaginally every 6 h up to a maximum of three doses in 24 h for second trimester pregnancy termination. METHODS: A total of 66 women seeking termination of second trimester pregnancy (30 fetal structural anomaly, six chromosomal abnormality and 30 fetal death) were randomly assigned to one of two treatment groups: (i) intravaginal misoprostol moistened with 3 ml of 5% acetic acid in group A (n = 33); or (ii) intravaginal misoprostol moistened with 3 ml of saline in group B (n = 33). RESULTS: The overall median (range) induction-abortion interval was 10 h (2-46) [10 h (4-35) in 36 live fetuses and 9 h (2-46) in 30 dead fetuses, P = 0.515]. All of the patients in both groups aborted within 48 h (100% success rate). The median (range) induction-abortion interval revealed a significantly faster delivery time (P < 0.001) in group A [8 h (2-24)] than in group B [14 h (3-46)]. CONCLUSIONS: This new regimen of 800 microg of vaginal misoprostol every 6 h for a maximum of three doses in 24 h was an effective alternative method for second trimester abortion. In addition, misoprostol moistened with acetic acid was significantly more effective than misoprostol moistened with saline. |
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Authors:
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Bulent Yilmaz; Sefa Kelekci; Ibrahim Egemen Ertas; Serkan Kahyaoglu; Murat Ozel; Necdet Sut; Nuri Danisman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2005-07-21 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 20 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-25 Completed Date: 2006-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 3067-71 Citation Subset: IM |
Affiliation:
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Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynaecology, Ankara, Turkey. drbulentyilmaz@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage Abortion, Induced / methods* Acetic Acid / administration & dosage* Administration, Intravaginal Adult Blood Pressure / drug effects Double-Blind Method Female Humans Misoprostol / administration & dosage*, adverse effects Pregnancy Pregnancy Trimester, Second* Prospective Studies Sodium Chloride / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol; 64-19-7/Acetic Acid; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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