Document Detail

Misoprostol moistened with acetic acid or saline for second trimester pregnancy termination: a randomized prospective double-blind trial.
MedLine Citation:
PMID:  16037107     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was conducted to evaluate the efficacy and side effects of a new regimen of 800 microg misoprostol administered intravaginally every 6 h up to a maximum of three doses in 24 h for second trimester pregnancy termination. METHODS: A total of 66 women seeking termination of second trimester pregnancy (30 fetal structural anomaly, six chromosomal abnormality and 30 fetal death) were randomly assigned to one of two treatment groups: (i) intravaginal misoprostol moistened with 3 ml of 5% acetic acid in group A (n = 33); or (ii) intravaginal misoprostol moistened with 3 ml of saline in group B (n = 33). RESULTS: The overall median (range) induction-abortion interval was 10 h (2-46) [10 h (4-35) in 36 live fetuses and 9 h (2-46) in 30 dead fetuses, P = 0.515]. All of the patients in both groups aborted within 48 h (100% success rate). The median (range) induction-abortion interval revealed a significantly faster delivery time (P < 0.001) in group A [8 h (2-24)] than in group B [14 h (3-46)]. CONCLUSIONS: This new regimen of 800 microg of vaginal misoprostol every 6 h for a maximum of three doses in 24 h was an effective alternative method for second trimester abortion. In addition, misoprostol moistened with acetic acid was significantly more effective than misoprostol moistened with saline.
Bulent Yilmaz; Sefa Kelekci; Ibrahim Egemen Ertas; Serkan Kahyaoglu; Murat Ozel; Necdet Sut; Nuri Danisman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-07-21
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-25     Completed Date:  2006-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  3067-71     Citation Subset:  IM    
Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynaecology, Ankara, Turkey.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage
Abortion, Induced / methods*
Acetic Acid / administration & dosage*
Administration, Intravaginal
Blood Pressure / drug effects
Double-Blind Method
Misoprostol / administration & dosage*,  adverse effects
Pregnancy Trimester, Second*
Prospective Studies
Sodium Chloride / administration & dosage*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol; 64-19-7/Acetic Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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