Document Detail


Misoprostol for medical evacuation of early pregnancy failure.
MedLine Citation:
PMID:  9166318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether misoprostol (a prostaglandin E1 analogue) 400 micrograms orally (group 1) or 800 micrograms vaginally (group 2) will cause complete uterine evacuation in women with early pregnancy failure. METHODS: Twenty subjects were recruited for a prospective, non-blinded, randomized clinical trial. Early pregnancy failure was diagnosed by transvaginal ultrasound examination; only women with a closed cervical os and minimal vaginal bleeding were enrolled. Subjects returned 24 hours after misoprostol administration for a transvaginal ultrasound examination. If the gestational sac was still present, the misoprostol dose was repeated and the subject returned again 24 hours later. Subjects who failed to expel the pregnancy were offered a suction curettage. RESULTS: Twelve and eight women were randomized to groups 1 and 2, respectively. Complete uterine evacuation occurred in three of 12 [25%, 95% confidence interval (CI) 1%, 50%] and seven of eight (88%, 95% CI 65%, 100%, P = .010) subjects in groups 1 and 2, respectively. Vomiting occurred in 30% and 13%, respectively, and diarrhea in 50% and 38%, respectively. CONCLUSION: Vaginal misoprostol 800 micrograms is more effective than oral misoprostol 400 micrograms for uterine evacuation of early pregnancy failure and may be an effective alternative to dilation and curettage.
Authors:
M D Creinin; R Moyer; R Guido
Related Documents :
19517278 - Antenatal ultrasound and postnatal autopsy findings in terminations after 12 weeks' ges...
15919088 - Controlling postpartum hemorrhage after home births in tanzania.
8968238 - Late selective termination of fetal abnormalities in twin pregnancies: a multicentre re...
15070888 - A randomized study comparing the use of sublingual to vaginal misoprostol for pre-opera...
14605868 - Phenotypic modulation of fibroblastic cells in mice pubic symphysis during pregnancy, p...
2683158 - The y anastomosis of césar roux.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, Pennsylvania, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects
Abortion, Missed / drug therapy*,  ultrasonography
Administration, Intravaginal
Administration, Oral
Adult
Diarrhea / chemically induced
Female
Humans
Misoprostol / administration & dosage*,  adverse effects
Pilot Projects
Pregnancy
Pregnancy Trimester, First
Prospective Studies
Vomiting / chemically induced
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenatal diagnosis of fetal primary cytomegalovirus infection.
Next Document:  Serum levels of inhibin A and inhibin B in women with normal and abnormal luteal function.