| Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 18043045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Misoprostol is a synthetic prostaglandin analog administered vaginally to induce labor for intrauterine death or termination of pregnancy for congenital abnormalities. We encountered a case of misoprostol induction of labor at 14 weeks of gestation for fetal acrania associated with amniotic bands. Histology demonstrated abundant deposits of refractile material appearing to be of vegetable fiber origin on the maternal surface of the fetal membranes. Misoprostol tablet scrapings had a similar microscopic appearance. Ten additional placentas from cases of misoprostol induction of labor between 16 and 18 weeks of gestation were examined and half were found to contain such deposits. No deposits were seen in cases between 15 and 18 weeks of gestation where misoprostol was not used. We attribute the refractile material to a nonmedicinal ingredient, microcrystalline cellulose, in the misoprostol tablet preparation. This study demonstrates that vaginal administration of misoprostol tablets can be detected microscopically in at least half of cases and may have a florid appearance simulating a potential causative factor of fetal malformation. Despite the large amounts of microcrystalline cellulose and its apparent embedding in placental tissue, the misoprostol in our index case was unlikely to have caused the amniotic bands and the resulting cranial abnormality. |
| | |
Authors:
|
Vincent Ho; Sarah Keating; John Kingdom; Patrick Shannon |
Related Documents
:
|
16291495 - Termination of pregnancy for fetal abnormality incompatible with life: women's experien... 940655 - Early pregnancy interruption by 15 (s) 15 methyl prostaglandin f2alpha methyl ester. 7443115 - Alternatives in midtrimester abortion induction. 473505 - Pregnancy termination in the control of the tibial hemimelia syndrome in galloway cattle. 10548635 - Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transf... 21442625 - Model predicted down syndrome detection rates for nuchal translucency screening in twin... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The American journal of surgical pathology Volume: 31 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-28 Completed Date: 2008-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 1893-6 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortifacient Agents, Nonsteroidal
/
administration & dosage,
adverse effects*,
chemistry Abortion, Induced* Administration, Intravaginal Adult Amniotic Band Syndrome / pathology Cellulose / adverse effects Excipients / adverse effects Female Fetus / abnormalities, pathology* Humans Infant, Newborn Misoprostol / administration & dosage, adverse effects*, chemistry Neural Tube Defects / pathology Placenta / pathology* Pregnancy |
| Chemical | |
Reg. No./Substance:
|
0/Abortifacient Agents, Nonsteroidal; 0/Excipients; 0/microcrystalline cellulose; 59122-46-2/Misoprostol; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphom...
Next Document: Porokeratoma.