Document Detail


Misoprostol (alone) in second trimester terminations of pregnancy: as effective as Gemeprost?
MedLine Citation:
PMID:  17000504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gemeprost (Cervagem) has been used widely compared with Misoprostol (Cytotec) alone in second trimester pregnancy termination. This prospective randomised trial was to evaluate the efficacy of intravaginal Misoprostol (alone) and Gemeprost in second trimester termination of pregnancy. A total of 54 women with 27 on each arm were involved. A total of 25 patients (92.6%) in the Misoprostol group and 22 patients (81.5%) in the Gemeprost group delivered within 48 h. The Misoprostol group delivered earlier, although average number of tablets required were similar. The side-effects were not significant between the two groups in fact, but there was more pyrexia in the Gemeprost group (p = 0.004). Misoprostol in second trimester termination of pregnancy is clinically as effective and less costly than the standard regimen of Gemeprost.
Authors:
M I Nor Azlin; H S N A Abdullah; M R Zainul Rashid; M A Jamil
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  26     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-26     Completed Date:  2007-01-25     Revised Date:  2007-02-15    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  546-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. azlinm@mail.uhkm.ukm.my
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects
Abortion, Induced*
Adult
Alprostadil / administration & dosage,  adverse effects,  analogs & derivatives*
Drug Costs
Female
Humans
Misoprostol / administration & dosage*,  adverse effects
Pregnancy
Pregnancy Trimester, Second
Treatment Outcome
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol; 64318-79-2/gemeprost; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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