Document Detail

Misoprostol alone for early abortion: an evaluation of seven potential regimens.
MedLine Citation:
PMID:  16022846     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: A growing body of literature has shown that misoprostol alone could be effective for early medical abortion. We evaluated seven potential regimens in women up to 56 days of gestation in order to potentially identify an optimal regimen. METHODS: In phase I of the study, women requesting early abortion were randomized to one of three misoprostol regimens (4x400 microg po every 3 h, 2x800 microg po every 6 h, 1x600 pv microg); in phase II, women were randomized to one of two regimens (2x800 microg po every 3 h, 1x800 pv microg). In phase III, we consecutively tested two regimens (800 microg pv wetted with saline repeated after 24 h if intact gestational sac, 2x800 microg pv wetted with saline) to validate previously published results. RESULTS: Although most women experienced some side effects, all regimens were tolerable and acceptable. Five of the seven regimens resulted in complete abortion rates of 60% or less. Only repeated doses of 800 microg pv misoprostol resulted in efficacy exceeding 60%. DISCUSSION: Misoprostol-alone abortion regimens using oral misoprostol are too ineffective for clinical use or further investigation. Regimens with repeated dosing of misoprostol 800 microg pv warrant further study to find the optimal treatment protocol.
Kelly Blanchard; Tara Shochet; Kurus Coyaji; Nguyen Thi Nhu Ngoc; Beverly Winikoff
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contraception     Volume:  72     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2006-08-07     Revised Date:  2007-01-30    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Ibis Reproductive Health, Cambridge, MA 02138, USA.
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MeSH Terms
Abdominal Pain / chemically induced
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects
Abortion, Induced / methods*
Drug Administration Schedule
Logistic Models
Misoprostol / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol
Comment In:
Contraception. 2006 Aug;74(2):176; author reply 176-7   [PMID:  16860060 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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