Document Detail

Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow.
MedLine Citation:
PMID:  14738166     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was designed to evaluate the effect of misoprostol on the blood flow in uterine arteries of pregnant women with first-trimester embryonic demise. METHODS: Transvaginal ultrasonographic Doppler examinations (resistance index, pulsatility index, systolic/diastolic ratio) of the uterine arteries in 61 pregnant women were performed before misoprostol administration and 90 min later. Following baseline Doppler measurements, each woman received 200 microg misoprostol intravaginally and 200 microg misoprostol orally. RESULTS AND CONCLUSION: All Doppler indices increased significantly after misoprostol administration (p < 0.0001), suggesting an increase in flow resistance.
C Turan; N Koc; R Dansuk; B Cengizoglu; D S Mericeli; O Unal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  14     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Kartal Education and Research Hospital, Istanbul, Turkey.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects
Abortion, Induced
Abortion, Missed
Administration, Intravaginal
Arteries / physiology*,  ultrasonography
Cohort Studies
Misoprostol / administration & dosage*,  adverse effects
Pregnancy Trimester, First
Pulsatile Flow / drug effects
Regional Blood Flow / drug effects
Ultrasonography, Doppler
Uterus / blood supply*,  ultrasonography
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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