Document Detail

The MisoPROM study: a multicenter randomized comparison of oral misoprostol and oxytocin for premature rupture of membranes at term.
MedLine Citation:
PMID:  14586349     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to determine whether induction of labor with oral misoprostol will result in fewer cesarean deliveries than intravenous oxytocin in nulliparous women with premature rupture of membranes at term. STUDY DESIGN: Three hundred five women at 10 centers were randomly assigned to receive oral misoprostol, 100 microg every 6 hours to a maximum of two doses or intravenous oxytocin. The primary outcome measure was cesarean deliveries. Secondary outcomes were time from induction to vaginal delivery and measures of maternal and neonatal safety. RESULTS: The study was stopped prematurely because of recruitment difficulties. We present the results for the 305 enrolled women. There was no difference in the proportion of women who underwent cesarean delivery (20.1% in the misoprostol group, 19.9% in the oxytocin group). The time interval from induction to vaginal delivery was also similar (11.9 hours for the misoprostol group, and 11.8 hours for the oxytocin group). Maternal and neonatal safety outcomes were similar for the two treatments. More infants born to women in the misoprostol group received intravenous antibiotics in the neonatal period (16.4% vs 6.9%, P=.01), although there were no differences in chorioamnionitis or in proven neonatal infections. Women receiving misoprostol were less likely to have postpartum hemorrhage than those receiving oxytocin (1.9% vs 6.2%, P=.05). CONCLUSION: Oral misoprostol does not offer any advantage in time from induction to vaginal delivery or risk of cesarean section.
Ellen Mozurkewich; Julie Horrocks; Suzanne Daley; Paul Von Oeyen; Melissa Halvorson; Mary Johnson; Michael Zaretsky; Mitra Tehranifar; Lucy Bayer-Zwirello; Alfred Robichaux; Sabine Droste; Garry Turner;
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-30     Completed Date:  2003-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1026-30     Citation Subset:  AIM; IM    
University of Michigan Medical Center, Ann Arbor, USA.
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MeSH Terms
Administration, Oral
Alprostadil / analogs & derivatives*
Cervical Ripening
Cesarean Section
Fetal Membranes, Premature Rupture / drug therapy*
Injections, Intravenous
Labor, Induced / methods*
Misoprostol / administration & dosage*
Oxytocin / administration & dosage*
Reg. No./Substance:
50-56-6/Oxytocin; 59122-46-2/Misoprostol; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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