Document Detail


Mismatch negativity and low frequency oscillations in schizophrenia families.
MedLine Citation:
PMID:  22541739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Theta-alpha range oscillations have been associated with MMN in healthy controls. Our previous studies showed that theta-alpha activities are highly heritable in schizophrenia patients' families. We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members.
METHODS: We compared MMN and single trial oscillations during MMN in 95 patients, 75 first-degree relatives, 87 controls, and 34 community subjects with schizophrenia spectrum personality (SSP) traits.
RESULTS: We found that (1) MMN was reduced in patients (p<0.001) and SSP subjects (p=0.047) but not in relatives (p=0.42); (2) there were augmented 1-20 Hz oscillations in patients (p=0.02 to <0.001) during standard and deviant stimuli; (3) theta-alpha (5-12 Hz) oscillations had the strongest correlation to MMN in controls and relatives (ΔR(2)=21.4-23.9%, all p<0.001), while delta (<5 Hz) showed the strongest correlation to MMN in schizophrenia and SSP trait subjects; and, (4) MMN (h(2)=0.56, p=0.002) and theta-alpha (h(2)=0.55, p=0.004) were heritable traits.
CONCLUSIONS: Low frequency oscillations have a robust relationship with MMN and the relationship appears altered by schizophrenia; and schizophrenia patients showed augmented low frequency activities during the MMN paradigm.
SIGNIFICANCE: The results encourage investigation of low frequency oscillations to elucidate the neurophysiological pathology underlying MMN abnormalities in schizophrenia.
Authors:
L Elliot Hong; Lauren V Moran; Xiaoming Du; Patricio O'Donnell; Ann Summerfelt
Related Documents :
9771249 - Bladder dysfunction and neurological disability at presentation in closed spina bifida.
9243039 - Central nervous system pneumocystosis in a patient with aids.
18720309 - Neurologic symptoms as a feature of the antiphospholipid syndrome.
10657409 - Identification of patients at risk for periprocedural neurological deficits associated ...
10851379 - Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating fa...
19234759 - Disorders of biopterin metabolism.
3090879 - Significance of isolation of aspergillus from the respiratory tract in diagnosis of inv...
1087569 - Practolol and ocular toxicity. antibodies in serum and tears.
22935349 - Utilization of ct perfusion patient selection for mechanical thrombectomy irrespective ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-25
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  123     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2012-11-20     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1980-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA. ehong@mprc.umaryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Waves / physiology*
Cerebral Cortex / physiopathology*
Electroencephalography
Evoked Potentials / physiology*
Family*
Female
Humans
Male
Middle Aged
Schizophrenia / genetics,  physiopathology*
Schizotypal Personality Disorder / genetics,  physiopathology*
Grant Support
ID/Acronym/Agency:
DA027680/DA/NIDA NIH HHS; MH049826/MH/NIMH NIH HHS; MH077852/MH/NIMH NIH HHS; MH085646/MH/NIMH NIH HHS; R01 DA027680/DA/NIDA NIH HHS; R01 MH049826/MH/NIMH NIH HHS; R01 MH077852/MH/NIMH NIH HHS; R01 MH085646/MH/NIMH NIH HHS; T32 MH067533/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of Mediterranean Diets on Kidney Function: A Report From the PREDIMED Trial.
Next Document:  Heartbeat evoked potentials mirror altered body perception in depressed patients.