Document Detail

Mismatch negativity (MMN) in multiple sclerosis: an event-related potentials study in 46 patients.
MedLine Citation:
PMID:  16325469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess pre-attentive detection mechanisms indexed by MMN component of auditory Event-Related Potentials (ERPs) in Multiple Sclerosis (MS) patients. METHODS: 46 MS patients (mean age 43.7 years, mean disease duration 10.1 years, mean EDSS 4.6) and 46 matched controls were assessed with ERPs elicited by a passive oddball paradigm using duration deviants. Auditory P50, N1, P2 components were recorded. MMN and P3a components were calculated as the difference potential between deviants and standard stimuli. Eighteen of these 46 patients underwent also global psychometrical assessment and were sorted in cognitively normal and impaired patients. ERPs of these two groups of patients were compared. RESULTS: MS patients showed reduced MMN and P3a areas as compared to controls, besides exogenous N1-P2 complex amplitude reduction. Among the 18 patients investigated with neuropsychological testings, six were cognitively impaired and 12 cognitively unimpaired. Patients with a global cognitive impairment had reduced MMN as compared to cognitively unimpaired patients. CONCLUSIONS: Auditory MMN and P3a components of auditory ERPs are altered in MS patients. MMN alterations are more pronounced in cognitively impaired patients. SIGNIFICANCE: MMN and P3a areas reduction suggests that MS patients are prone to pre-attentive auditory information processing deficits, besides previously described controlled information processing difficulties. Moreover, MMN alterations may represent an objective index of cognitive disturbances in MS patients.
Julien Jung; Dominique Morlet; Bernadette Mercier; Christian Confavreux; Catherine Fischer
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-12-01
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  117     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-12     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-93     Citation Subset:  IM    
Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France.
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MeSH Terms
Acoustic Stimulation / methods
Case-Control Studies
Chi-Square Distribution
Cognition Disorders / etiology
Contingent Negative Variation / physiology*
Evoked Potentials / physiology*
Middle Aged
Multiple Sclerosis / complications,  physiopathology*
Neuropsychological Tests
Psychometrics / methods
Reaction Time

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