| Mismatch negativity (MMN) in multiple sclerosis: an event-related potentials study in 46 patients. | |
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MedLine Citation:
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PMID: 16325469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess pre-attentive detection mechanisms indexed by MMN component of auditory Event-Related Potentials (ERPs) in Multiple Sclerosis (MS) patients. METHODS: 46 MS patients (mean age 43.7 years, mean disease duration 10.1 years, mean EDSS 4.6) and 46 matched controls were assessed with ERPs elicited by a passive oddball paradigm using duration deviants. Auditory P50, N1, P2 components were recorded. MMN and P3a components were calculated as the difference potential between deviants and standard stimuli. Eighteen of these 46 patients underwent also global psychometrical assessment and were sorted in cognitively normal and impaired patients. ERPs of these two groups of patients were compared. RESULTS: MS patients showed reduced MMN and P3a areas as compared to controls, besides exogenous N1-P2 complex amplitude reduction. Among the 18 patients investigated with neuropsychological testings, six were cognitively impaired and 12 cognitively unimpaired. Patients with a global cognitive impairment had reduced MMN as compared to cognitively unimpaired patients. CONCLUSIONS: Auditory MMN and P3a components of auditory ERPs are altered in MS patients. MMN alterations are more pronounced in cognitively impaired patients. SIGNIFICANCE: MMN and P3a areas reduction suggests that MS patients are prone to pre-attentive auditory information processing deficits, besides previously described controlled information processing difficulties. Moreover, MMN alterations may represent an objective index of cognitive disturbances in MS patients. |
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Authors:
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Julien Jung; Dominique Morlet; Bernadette Mercier; Christian Confavreux; Catherine Fischer |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-12-01 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 117 ISSN: 1388-2457 ISO Abbreviation: Clin Neurophysiol Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-04-12 Revised Date: 2008-09-10 |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 85-93 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France. jung@lyon.inserm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Adult Case-Control Studies Chi-Square Distribution Cognition Disorders / etiology Contingent Negative Variation / physiology* Electroencephalography Evoked Potentials / physiology* Female Humans Male Middle Aged Multiple Sclerosis / complications, physiopathology* Neuropsychological Tests Psychometrics / methods Reaction Time |
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