Document Detail

Mismatch negativity (MMN) as an index of auditory sensory memory deficit in cleft-palate and CATCH syndrome children.
MedLine Citation:
PMID:  9760106     Owner:  NLM     Status:  MEDLINE    
Our recent study demonstrated with the brain's automatic change-detection response, the mismatch negativity (MMN) of the event-related potentials (ERPs), that the duration of auditory sensory memory is significantly shorter in school-age children with CATCH syndrome than in healthy age-matched controls. One of the characteristic symptoms of this syndrome, caused by a microdelection in chromosome 22, is cleft palate. The most common problems in these children, however, are learning difficulties and, according to our results, it is likely that these problems are not due to the dysmorphology of peripheral speech mechanisms only but are also caused by CNS dysfunctions. In the present study we show with MMN that auditory sensory memory is also shortened in school-age children with cleft palate but without the CATCH syndrome. It has been shown in previous studies with neuropsychological tests that although children with cleft palate have language and learning-related problems these difficulties are usually less severe than those of CATCH children. Likewise the present study demonstrates that the auditory sensory memory trace seems to decay more rapidly in CATCH children than in children with cleft palate.
M Cheour; M L Haapanen; R Ceponiene; J Hukki; R Ranta; R Näätänen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  9     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-29     Completed Date:  1998-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2709-12     Citation Subset:  IM    
Department of Psychology, University of Helsinki, Finland.
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MeSH Terms
Abnormalities, Multiple / psychology*
Acoustic Stimulation
Cleft Palate / psychology*
Evoked Potentials, Auditory / physiology
Hearing / physiology*
Memory Disorders / psychology*

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