| Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. | |
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MedLine Citation:
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PMID: 10595508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms that establish the dorsal-ventral (D-V) axis of the eye are poorly understood. We isolated two homeobox genes from mouse and chicken, mVax2 and cVax, whose expression during early eye development is restricted to the ventral retina. In chick, ectopic expression of either Vax leads to ventralization of the early retina, as assayed by expression of the transcription factors Pax2 and Tbx5, and the Eph family members EphB2, EphB3, ephrinB1, and ephrinB2, all of which are normally dorsally or ventrally restricted. Moreover, the projections of dorsal but not ventral ganglion cell axons onto the optic tectum showed profound targeting errors following cVax misexpression. mVax2/cVax thus specify positional identity along the D-V axis of the retina and influence retinotectal mapping. |
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Authors:
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D Schulte; T Furukawa; M A Peters; C A Kozak; C L Cepko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuron Volume: 24 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-04 Completed Date: 2000-01-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 541-53 Citation Subset: IM |
Affiliation:
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Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF117299 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence
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genetics Animals Avian Proteins* Chick Embryo / physiology Cloning, Molecular Embryonic and Fetal Development / physiology Eye / embryology Gene Expression / physiology* Genes, Homeobox / genetics* Homeodomain Proteins / genetics* Mice / embryology Molecular Sequence Data Receptor Protein-Tyrosine Kinases / metabolism Receptor, EphB4 Receptors, Eph Family Retina / embryology* Superior Colliculi / embryology* Transcription Factors Visual Pathways / embryology* |
| Grant Support | |
ID/Acronym/Agency:
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T32 EYO 7110/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Avian Proteins; 0/Homeodomain Proteins; 0/Transcription Factors; 0/Vax protein, chicken; 0/Vax2 protein, mouse; 0/empty spiracles homeobox proteins; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, EphB4; EC 2.7.10.1/Receptors, Eph Family |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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